科学研究
发表论著
2020年发表论文
| 作者 | 标题 | 期刊名 |
| Du X#, Zhou L#, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, Yang H* | ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. | J Cell Biol |
| Chen FJ, Yin Y, Chua BT, Li P* | CIDE family proteins control lipid homeostasis and the development of metabolic diseases. | Traffic |
| Lv X#, Liu J#, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P* | Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. | Biochim Biophys Acta Mol Cell Biol Lipids |
| Mei XY, Qi DS, Zhang T, Zhao Y, Jin L, Hou JL, Wang JH, Lin Y, Xue Y, Zhu PP, Liu ZX, Huang L, Nie J, Si W, Ma JY, Ye JH, Finnell R H, Saiyin H, Wang HY, Zhao JY, Zhao SM, Xu W | Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects. | EMBO Molecular Medicine |
| Qu YY, Zhao R, Zhang HL, Zhou Q, Xu FJ, Zhang X, Xu WH, Shao N, Zhou SX, Dai B, Zhu Y, Shi GH, Shen YJ, Zhu YP, Han CT, Chang K, Lin Y, Zang WD, Xu W, Ye DW, Zhao SM, Zhao JY | Inactivation of the AMPK-GATA3-ECHS1 pathway induces fatty acid synthesis that promotes clear cell renal cell carcinoma growth. | Cancer Research |
| Wang L#, Zhang Y#, Fu X#, Dong S#, Tang S, Zhang N, Song C, Yang N, Zhang L, Wang H, Shi H, Jin L, Zhang F*, Li J#, Hua K* | Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies | Cell Research |
| Tian-Yi Jiang, Yu-Fei Pan, Zheng-Hua Wan, Yun-Kai Lin, Bin Zhu, Zhen-gang Yuan,Yun-Han Ma, Yuan-Yuan Shi, Tian-Mei Zeng, Li-Wei Dong*, Ye-Xiong Tan& Hong-Yang Wang*. | PTEN status determines the chemosensitivity to proteasome inhibition in cholangiocarcinoma. | Science Translational Medicine |
| Xiaofang Zhao, Wenhao Qin, Youhai Jiang, Zhishi Yang, Bo Yuan, Rongyang Dai, Hao Shen, Yao Chen, Jing Fu*, Hongyang Wang*. | ACADL plays a tumor-suppressor role by targeting Hippo/YAP signaling in hepatocellular carcinoma | npj Precision Oncology |
| Qin WH, Yang ZS, Li M, Chen Y, Zhao XF, Qin YY, Song JQ, Wang BB, Yuan B, Cui XL, Shen F, He J, Bi YF, Ning G*, Fu J*, Wang HY*. | High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice. | Gastroenterology |
| Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L*, Wang H*. | A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. | Hepatology |
2019年发表论文
| 作者 | 标题 | 期刊名 |
| Lv X#, Liu J#, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P*. | Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. | Biochim Biophys Acta Mol Cell Biol Lipids |
| Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P*. | The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. | Cell Rep |
| Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X, Li P. | Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. | EMBO J |
| Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L. | Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. | PLoS Biol |
| Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB. | SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. | Proc Natl Acad Sci U S A |
| Li QQ , Zhao QY, Zhang JY, Zhou LK, Zhang WH, Chua BT, Chen Y, Xu L, Li P. | The protein phosphatase 1 complex is a direct target of AKT that links insulin signaling to hepatic glycogen deposition. | Cell Reports |
| Xie Y, Ma A, Wang B, Peng R, Jing Y Wang D, Finnell RH, Qiao B, Wang Y, Wang H, Zheng Y. | Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. | Clin Sci (Lond) |
| Wang YM, Zheng YF, Yang SY, Yang ZM, Zhang LN, He YQ, Gong XH, Liu D, Finnell RH, Qiu ZL, Du YS, Wang HY. | MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. | Cell Death Differ |
| Zhang L, Qin Y, Gong X, Peng R, Cai C, Zheng Y, Du Y, Wang H. | A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. | Transl Psychiatry |
| Shi Z, Chen S1, Han X, Peng R, Luo J, Yang L, Zheng Y, Wang H. | The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defects. | Mol Cytogenet |
| Zhang H, Guo Y, Gu H, Wei X, Ma W, Liu D, Yu K, Luo W, Ma L, Liu Y, Xue J, Huang J, Wang Y, Jia S, Dong N, Wang H, Yuan Z. T | RIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis. | Clin Epigenetics |
| Li Y, Yao CF, Xu FJ, Qu YY, Li JT, Lin Y, Cao ZL, Lin PC, Xu W, Zhao SM, Zhao JY. | APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. | Nat Commun |
| Liu C, He X, Liu W, Yang S, Wang L, Li W, Wu H, Tang S, Ni X, Wang J, Gao Y, Tian S, Zhang L, Cong J, Zhang Z, Tan Q, Zhang J, Li H, Zhong Y, Lv M, Li J, Jin L, Cao Y*, Zhang F*. | Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice. | American Journal of Human Genetics |
| Li W, He X, Yang S, Liu C,Wu H, Liu W, Lv M, Tang D, Tan J, Tang S, Chen Y, Wang J, Zhang Z, Wang H, Jin L, Zhang F, Cao Y. | Biallelic mutations of CFAP251 cause sperm flagellar defects and human male infertility. | Journal of Human Genetic |
| Wang Q, Li D, Cai B, Chen Q, Li C, Wu Y, Jin L, Wang X, Zhang X, Zhang F. | Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlations. | Human Genetic |
| Liu W, Wu H, Wang L, Yang X, Liu C, He X, Li W, Wang J, Chen Y, Wang H, Gao Y, Tang S, Yang S, Jin L, Zhang F, Cao Y. | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia. | Journal of Genetics and Genomics |
| Yang N, Wu N, Zhang L, Zhao Y, Liu J, Liang X, Ren X, Li W, Chen W, Dong S, Zhao S, Lin J, Xiang H, Xue H,Chen L, Sun H, Zhang J, Shi J, Zhang S, Lu D, Wu X, Jin L, Ding J, Qiu G, Wu Z, Lupski JR, Zhang F. | TBX6 compound inheritance leads to congenital vertebral malformations in humans and mice. | Human Molecular Genetics |
| He X, Li W, Wu H, Lv M, Liu W, Liu C, Zhu F, Li C, Fang Y, Yang C, Cheng H, Zhang J, Tan J, Chen T, Tang D, Song B, Wang X, Zha X, Wang H, Wei Z, Yang S, Saiyin H, Zhou P, Jin L, Wang J, Zhang Z, Zhang F, Cao Y. | Novel homozygous CFAP69 mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagella. | Journal of Medical Genetics |
| Dong S, Wang C, Li X, Shen Q, Fu X, Wu M, Song C, Yang N, Wu Y, Wang H, Jin L, Xu H, Zhang F. | Noncoding rare variants of TBX6 in congenital anomalies of the kidney and urinary tract. | Molecular Genetics and Genomics |
| Liu W, He X, Yang S, Zouari R, Wang J, Wu H, Kherraf ZE, Liu C, Coutton C, Zhao R, Tang D, Tang S, Lv M, Fang Y, Li W, Li H, Zhao J, Wang X, Zhao S, Zhang J, Arnoult C, Jin L, Zhang Z, Ray PF, Cao Y, Zhang F. | Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice. | American Journal of Human Genetics |
| Wu H, Li W, He X, Liu C, Fang Y, Zhu F, Jiang H, Liu W, Song B, Wang X, Zhou P, Wei Z, Zhang F, Cao Y. | Novel CFAP43 and CFAP44 mutations cause male infertility with multiple morphological abnormalities of the sperm flagella (MMAF). | Reproductive BioMedicine Online |
| Liu C, Lv M, He X, Zhu Y, Amiri-Yekta A, Li W, Wu H, Kherraf ZE, Liu W, Zhang J, Tan Q, Tang S, Zhu YJ, Zhong Y, Li C, Tian S, Zhang Z, Jin L, Ray P, Zhang F, Cao Y. | Homozygous mutations in SPEF2 induce multiple morphological abnormalities of the sperm flagella and male infertility. | Journal of Medical Genetics |
| Wang R*, Guo S, Tian H, Huang Y, Yang Q, Zhao K, Kuo CH, Hong S, Chen P*, Liu T*. | Hypoxic training in obese mice improves metabolic disorder. | Front Endocrinol, |
| Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC. | Pyruvate-carboxylase-mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver. | Cell Metabolisum |
| Cordonier EL, Liu T, Saito K, Chen SS, Xu Y, Fukuda M. | Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression. | Journal of the Endocrine Society |
| Ou Z#, Ma Y#, Sun Y#, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR*, Zhao TJ*, Chen Y*. | A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. | Cell Rep, |
| Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. | DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. | Cell Rep |
| J Wang, B T Chua, P Li, and F-J Chen. | Lipid-exchange rate assay for lipid droplet fusion in live cells. | Bio-protocol |
| Min Yuan*, Daniel M. Kremer*, He Huang*, Susanne B. Breitkopf, Issam Ben Sahra, Brendan D. Manning, Costas A. Lyssiotis, John M. Asara. | Ex Vivo and In Vivo Stable Isotope Labelling of Central Carbon Metabolism and Related Pathways with analysis by LC-MS/MS. | Nature Protocols |
| Wen Cai Zhang, Julie Wells, Kin-Hoe Chow, He Huang, Min Yuan, Tanvi Saxena, Mary Ann Melnick, Katerina Politi, John Asara, Daniel Costa, Carol Bult, Frank Slack . | miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. | Nature Metabolism |
| Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, Shi G, Ge Y, Gao P, Yang Y, Ke A, Xiao L, Dong R, Zhu Y, Yang X, Wang J, Zhu T, Yang D, Huang X, Sui C, Qiu S, Shen F, Sun H, Zhou W, Zhou J, Nie J, Zeng C, Stroup EK, Zhang X, Chiu BC, Lau WY, He C, Wang H, Zhang W, Fan J. | Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. | Gut |
| Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W*, Wang H*, Ding J*. | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. | Cell Res |
| Liu J, Jiang J, Mo J, Liu D, Cao D, Wang H, He Y, Wang H*. | Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. | Hepatology |
| Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B, He ZY, Wang HY*, Yan HX*. | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. | Cell Res |
| Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J, Liao S, Hu M, Wang Y, Zhang D, Hu C, Xiong X, Li XY. | Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14. | Proc Natl Acad Sci U S A |
2018年发表论文
| 作者 | 标题 | 期刊名 |
| Xu D , Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG., Yang H, Li P. | Rab18 promotes lipid droplet growth by tethering ER and LD through interaction between NRZ and SNARE. | J Cell Biol |
| Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P, Xu L. | Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes. | Diabetes |
| Wang J, Yan C, Xu C, Chua BT, Li P, Chen FJ. | Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. | J Biol Chem |
| Lv X, Liu J, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P. | Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. | Biochim Biophys Acta (Mol Cell Biol Lipids) |
| Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY. | Finnell RH. Formate rescues neural tube defects caused by mutations in Slc25a32. | Proc Natl Acad Sci U S A |
| Chen Z, Kuang L, Finnell RH, Wang H. | Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort. | Hum Genet |
| Li B, Yu L, Liu D, Yang X, Zheng Y, Gui Y, Wang H. | MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease. | Clin Sci (Lond) |
| Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. | Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. | Cell Res |
| Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell R, Zhang T, Wang H. | Genetic analysis of Wnt/PCP genes in neural tube defects. | BMC Med Genomics |
| Chen Z, Kuang L, Finnell RH, Wang H. | Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort. | Hum Genet |
| He XD, Gong W, Zhang JN, Nie J, Yao CF, Guo FS, Lin Y, Wu XH, Li F, Li J, Sun WC, Wang ED, An YP, Tang HR, Yan GQ, Yang PY, Wei Y, Mao YZ, Lin PC, Zhao JY, Xu YH, Xu W, Zhao SM. | Sensing and transmitting intracellular amino acid signals through reversible lysine aminoacylations. | Cell Metabolism |
| Zhang Q, Bai B, Mei X, Wan C, Cao H, Dan Li, Wang S, Zhang M, Wang Z, Wu J, Wang H, Huo J, Ding G, Zhao J, Xie Q, Wang L, Qiu Z, Zhao S, Zhang T. | Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects. | Nat Commun |
| Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. | Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. | Cell Metabolism |
| Wei Q, Gu YF, Zhang QJ, Yu H, Peng Y, Williams KW, Wang R, Yu K, Liu T, Liu ZP. | Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. | Journal of Molecular Cell Biology |
| Qian H, Chen Y, Huang T, Liu T, Li X, Jiang G, Zhang W, Cheng S, Li P. | Combined application of Embelin and tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and invasion in osteosarcoma cells via caspase-induced apoptosis. | Oncology Letters |
| Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW. | Phosphoinositide 3-kinase is integral for the acute activity of leptin and insulin in male arcuate NPY/AgRP neurons. | Journal of the Endocrine Society |
| Zhang X, Niu Y, Wang X, Liu ZP, Liu T, Wang RT. | Mean platelet volume and platelet distribution width are associated with gallbladder cancer. | Asian Pacific Journal of Cancer Prevention |
| Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, Wang B, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC. | An Hsp20-FBXO4 axis regulates adipocyte function through modulating PPARγ ubiquitination. | Cell Reports |
| Liu M#, Zeng T#, Zhang X#, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ*, Wang HR*. | ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. | Nat Commun |
| Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, Cao D, Tang L, Tang S, Wu M, Yang W*, Wang H*. | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. | Nat Commun |
| Zhao J, Xiong X, Li Y, Liu X, Wang T, Zhang H, Jiao Y, Jiang J, Zhang H, Tang Q, Gao X, Li X, Lu Y, Liu B, Hu C, Li XY. | Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A. | Diabetes |
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